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Is It Time to Reconsider Rituximab Dosing Regimens for Pemphigus Vulgaris?

Christian CiolfiJacopo TartagliaMauro Alaibac
Published in: Antibodies (Basel, Switzerland) (2024)
Rituximab is currently approved for patients affected by moderate-to-severe pemphigus vulgaris, a severe autoimmune blistering skin disease that can be life-threatening. The standard rituximab dosing regimens, originally established for B-cell non-Hodgkin's lymphomas, have been recognized to exceed the effective dose required for inducing B-cell depletion, considering that the B-cell burden in pemphigus vulgaris is considerably lower than in lymphoproliferative disorders. We herein report our experience with very ultra-low-dose rituximab in two patients affected by pemphigus vulgaris.
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