Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Luca LazzariGiorgio CortiGabriele PiccoClaudio Isella Monica MontonePamela ArcellaErika DurinikovaEugenia R ZanellaLuca NovaraFabiane BarbosaAndrea CassingenaCarlotta CancelliereEnzo MedicoAndrea Sartore-Bianchi Salvatore Siena Mathew J GarnettAndrea BertottiLivio TrusolinoFederica Di Nicolantonio Michael LinnebacherAlberto BardelliSabrina Arena

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

The XL platform represents a preclinical tool for functional gene validation and proof-of-concept studies to identify novel druggable vulnerabilities in colorectal cancer.

Keyphrases

high throughput
copy number
genome wide
stem cells
clinical decision support
case control
gene expression
bone marrow
single cell