Evidences of CTLA-4 and PD-1 Blocking Agents-Induced Cardiotoxicity in Cellular and Preclinical Models.

Vincenzo QuagliarielloMargherita PassarielloDomenica ReaAntonio BarbieriMartina IovineAnnamaria BonelliAntonietta CaronnaGerardo BottiClaudia De LorenzoNicola Maurea

Published in: Journal of personalized medicine (2020)

Nivolumab and Ipilimumab exert cytotoxic effects mediated by the NLRP3/IL-1β and MyD88 pathways, leading to pro-inflammatory cytokine storm in heart tissue.

Keyphrases

high glucose
heart failure
diabetic rats
toll like receptor
cell therapy
drug induced
endothelial cells
stem cells
bone marrow
immune response
inflammatory response