Poly(glycidol) Coating on Ultrahigh Molecular Weight Polyethylene for Reduced Biofilm Growth.
Jacob N LockhartThomas J SpoonmoreMichael W McCurdyBridget R RogersScott A GuelcherEva HarthPublished in: ACS applied materials & interfaces (2018)
Semibranched poly(glycidol) (PG-OH) and poly(glycidol allylglycidyl ether) (PG-Allyl) coatings were formed on ultrahigh molecular weight polyethylene (UMWPE) in a unique two-step process which included radiation of UHMWPE followed by grafting of PG-OH or PG-Allyl to the surface via free radical cross-linking. Resulting surfaces were extensively characterized by FTIR-ATR, XPS, fluorescent microscopy, and contact goniometry. The performance was evaluated using the most prominent biofilm-forming bacteria Staphylococcus aureus for 24 and 48 h. The PG-Allyl coating demonstrated a 3 log reduction in biofilm growth compared to noncoated control, demonstrating a promising potential to inhibit adherence and colonization of biofilm-forming bacteria that often develop into persistent infections.
Keyphrases
- staphylococcus aureus
- biofilm formation
- pseudomonas aeruginosa
- candida albicans
- methicillin resistant staphylococcus aureus
- quantum dots
- high throughput
- cystic fibrosis
- escherichia coli
- high resolution
- multidrug resistant
- optical coherence tomography
- oxidative stress
- adipose tissue
- single molecule
- dna damage
- living cells
- label free
- climate change
- skeletal muscle
- high speed
- human health
- risk assessment
- fluorescent probe
- weight loss