C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer.
Kosuke SasakiShigetsugu TakanoSatoshi TomizawaYoji MiyaharaKatsunori FurukawaTsukasa TakayashikiSatoshi KubokiMamoru TakadaMasayuki OhtsukaPublished in: Journal of experimental & clinical cancer research : CR (2021)
These findings demonstrate that the combination of GnP therapy with C4BPA inhibits PDAC progression by promoting antitumor T cell accumulation in the tumor microenvironment.