Hepcidin and DNA promoter methylation in hepatocellular carcinoma.

Silvia UdaliAnnalisa CastagnaMichela CorbellaAndrea RuzzenenteSara MoruzziFilippo MazziTommaso CampagnaroDomenica De SantisAntonia FranceschiPatrizia PattiniRossella GottardoOliviero OlivieriLuigi PerbelliniAlfredo GuglielmiSang-Woon ChoiDomenico GirelliSimonetta Friso

Published in: European journal of clinical investigation (2017)

This study highlights a novel role for HAMP downregulation through DNA promoter hypermethylation and emphasises the significance of epigenetics in the regulation of iron metabolism in HCC.

Keyphrases

dna methylation
circulating tumor
cell free
single molecule
transcription factor
gene expression
genome wide
cell proliferation
signaling pathway
iron deficiency
nucleic acid