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Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.

Eleonora MäkeläKarolina PavicTaru VarilaUrpu SalmenniemiEliisa LöyttyniemiSrikar G NagelliTea AmmunetVeli-Matti KähäriRichard E ClarkLaura L EloVenkata Kumari BachanaboyinaClaire M LucasMaija Itälä-RemesJukka Westermarck
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We discovered a novel variant of the oncoprotein CIP2A and its clinical relevance in predicting tyrosine kinase inhibitor therapy resistance in myeloid leukemias.
Keyphrases
  • dendritic cells
  • bone marrow
  • acute myeloid leukemia
  • small molecule
  • tyrosine kinase
  • high throughput
  • advanced non small cell lung cancer
  • immune response
  • mesenchymal stem cells