cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice.

Yaning LiShuang ChangWanlu LiGuanghui TangYuanyuan MaYanqun LiuFang YuanZhijun ZhangGuo-Yuan YangYongting Wang

Published in: Stem cell research & therapy (2018)

The synergistic treatment of CXCL12-EPCs outperformed the single therapies of GFP-EPCs or LV-CXCL12 gene therapy in various aspects related to post-ischemic brain repair. cxcl12-engineered EPCs hold great potential in the treatment of ischemic stroke.

Keyphrases

brain injury
cerebral ischemia
gene therapy
subarachnoid hemorrhage
endothelial cells
atrial fibrillation
ischemia reperfusion injury
metabolic syndrome
type diabetes
vascular endothelial growth factor
multiple sclerosis
adipose tissue
drug delivery
risk assessment
replacement therapy
wound healing