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Study of Carbamoyl Fluoride: Synthesis, Properties and Applications.

Clémence BonnefoyEmmanuel ChefdevilleChristian TourvieilleArmen PanosianGilles HanquetFrédéric R LerouxFabien ToulgoatThierry Billard
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride is presented. Stability studies, in particular under physiological conditions, and lipophilicity measurement were performed. A new easy, safe, inexpensive, and metal-free synthesis method is also described. Finally, a potential use in radiochemistry through a 18 F/ 19 F isotopic exchange is demonstrated.
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