Diagnosis of depression in multiple sclerosis is predicted by frontal-parietal white matter tract disruption.

Kira AshtonTom A FuchsDevon OshipRobert ZivadinovDejan JakimovskiNiels BergslandDeepa P RamasamyCaila VaughnBianca Weinstock-GuttmanRalph H B BenedictMichael G Dwyer

Published in: Journal of neurology (2020)

Baseline CFPN disruption is associated with progression to clinical depression over 5 years in PwMS. Development of new WM pathology within this network may be a risk factor for depression.

Keyphrases

multiple sclerosis
white matter
depressive symptoms
sleep quality
physical activity
functional connectivity