The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.

Edyta MajorczykAndrzej WiśniewskiAleksandra Zoń-GiebelArkadiusz ChlebickiPiotr WilandPiotr Kuśnierczyk

Published in: International journal of immunogenetics (2019)

LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.

Keyphrases

ankylosing spondylitis
immune response
disease activity
rheumatoid arthritis
systemic lupus erythematosus
genome wide
dendritic cells
gene expression
transcription factor
inflammatory response
bioinformatics analysis