Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.

Mijung KwonGenesaret RubioHaitao WangGregory M RiedlingerAsha AdemHua ZhongDaniel SlegowskiLouisa Post-ZwickerAnshruta ChidanandaDavid S SchrumpSharon R Pine Steven K Libutti

Published in: Cancer research communications (2022)

This study identifies FILIP1L as a tumor suppressor in LUADs and demonstrates that downregulation of FILIP1L is a clinically relevant event in the pathogenesis and clinical course of these neoplasms.

Keyphrases

cell proliferation
signaling pathway
oxidative stress
genome wide
smoking cessation
gene expression
dna methylation