Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2.

Racquel Domingo-GonzalezGiovanny J Martínez-ColónAlana J SmithCarolyne K SmithMegan N BallingerMeng XiaSusan MurrayMariana J KaplanGregory A YanikBethany B Moore

Published in: American journal of respiratory and critical care medicine (2016)

Our results suggest blockade of the PGE2-EP2 or EP4 signaling pathway restores NETosis after transplantation. Furthermore, these data provide the first description of a physiologic inhibitor of NETosis.

Keyphrases

stem cells
signaling pathway
pi k akt
electronic health record
cell therapy
big data
epithelial mesenchymal transition
induced apoptosis
machine learning
cell proliferation
data analysis