Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study.
Pomme I H G SimonsMerel E B CornelissenOlivier ValkenburgN Charlotte Onland-MoretYvonne T van der SchouwCoen D A StehouwerStephen BurgessMartijn C G J BrouwersPublished in: Clinical endocrinology (2021)
These sex-specific analyses show that the genetically predicted risk of PCOS is not associated with the risk of CAD. Instead, the genetically predicted risk of obesity (and its downstream metabolic effects) is the common denominator of both PCOS and CAD risk.
Keyphrases
- polycystic ovary syndrome
- coronary artery disease
- insulin resistance
- metabolic syndrome
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- adipose tissue
- type diabetes
- high fat diet induced
- skeletal muscle
- weight gain
- aortic stenosis
- transcatheter aortic valve replacement
- atrial fibrillation