Benefits of the Neurogenic Potential of Melatonin for Treating Neurological and Neuropsychiatric Disorders.
Yaiza PotesCristina Cachán-VegaEduardo AntuñaClaudia Garcia-GonzalezNerea Menéndez-CotoJose Antonio BogaJosé Gutiérrez-RodríguezManuel BermúdezVerónica SierraIgnacio Vega-NaredoAna Coto-MontesBeatriz CaballeroPublished in: International journal of molecular sciences (2023)
There are several neurological diseases under which processes related to adult brain neurogenesis, such cell proliferation, neural differentiation and neuronal maturation, are affected. Melatonin can exert a relevant benefit for treating neurological disorders, given its well-known antioxidant and anti-inflammatory properties as well as its pro-survival effects. In addition, melatonin is able to modulate cell proliferation and neural differentiation processes in neural stem/progenitor cells while improving neuronal maturation of neural precursor cells and newly created postmitotic neurons. Thus, melatonin shows relevant pro-neurogenic properties that may have benefits for neurological conditions associated with impairments in adult brain neurogenesis. For instance, the anti-aging properties of melatonin seem to be linked to its neurogenic properties. Modulation of neurogenesis by melatonin is beneficial under conditions of stress, anxiety and depression as well as for the ischemic brain or after a brain stroke. Pro-neurogenic actions of melatonin may also be beneficial for treating dementias, after a traumatic brain injury, and under conditions of epilepsy, schizophrenia and amyotrophic lateral sclerosis. Melatonin may represent a pro-neurogenic treatment effective for retarding the progression of neuropathology associated with Down syndrome. Finally, more studies are necessary to elucidate the benefits of melatonin treatments under brain disorders related to impairments in glucose and insulin homeostasis.
Keyphrases
- cerebral ischemia
- anti inflammatory
- spinal cord injury
- subarachnoid hemorrhage
- cell proliferation
- resting state
- blood brain barrier
- traumatic brain injury
- white matter
- brain injury
- amyotrophic lateral sclerosis
- type diabetes
- functional connectivity
- oxidative stress
- multiple sclerosis
- adipose tissue
- climate change
- skeletal muscle
- risk assessment
- bipolar disorder
- neural stem cells
- ischemia reperfusion injury
- blood glucose
- pi k akt
- blood pressure
- case control
- drug induced