Assessment of Liver Graft Steatosis: Where Do We Stand?
Manuela CesarettiPietro AddeoLuigi SchiavoRodolphe AntyAntonio IannelliPublished in: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2020)
The growing number of patients on waiting lists for liver transplantation and the shortage of organs have forced many centers to adopt extended criteria for graft selection, moving the limit of acceptance for marginal livers. Steatotic grafts that were, in the past, considered strictly unacceptable for transplantation because of the high risk of early nonfunction are now considered as a potential resource for organ implementation. Several methods to diagnose, measure, classify, and stage steatosis exist, but none can be considered qualitatively and quantitatively "the ideal method" to date. Clinical, biological, and imaging data can be very helpful to estimate graft steatosis, but histology still remains the gold standard. There is an increasing need for rapid and reliable tools to assess graft steatosis. Herein, we present a comprehensive review of the approaches that are currently used to quantify steatosis in liver grafts.
Keyphrases
- insulin resistance
- high fat diet
- high fat diet induced
- end stage renal disease
- adipose tissue
- ejection fraction
- healthcare
- newly diagnosed
- metabolic syndrome
- primary care
- chronic kidney disease
- skeletal muscle
- prognostic factors
- peritoneal dialysis
- electronic health record
- quality improvement
- machine learning
- risk assessment
- fluorescence imaging