The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT.

Margherita RiminiPierfrancesco FrancoFederica BertoliniDe Bari BerardinoZampino Maria GiuliaVegge StefanoKalliopi AndrikouFrancesca ArcadipaneMartina NapolitanoLavajo Vieira BunoGerardi Marianna AlessandraFrancesco OliveroFilippo FerreriUmberto RicardiStefano CascinuAndrea Casadei-Gardini

Published in: Journal of gastrointestinal cancer (2022)

Eosinophil count could be used as a prognostic factor in anal HPV-positive SCC. The worse prognosis showed in HPV-positive patients with high eosinophil count is likely to derive from an unfavorable interaction between the HPV-induced immunomodulation and eosinophils, which may hamper the curative effect of RT.

Keyphrases

high grade
prognostic factors
cervical cancer screening
computed tomography
peripheral blood
high glucose
oxidative stress
diabetic rats
drug induced
contrast enhanced
endothelial cells
positron emission tomography