Pathophysiology of severe primary graft dysfunction in orthotopic heart transplantation.

Hoong Sern LimAaron RanasingheDavid QuinnColin D ChueJorge Mascaro

Published in: Clinical transplantation (2021)

Severe PGD of the dominant right heart failure phenotype is characterized by reduced chamber capacitance, increased "stiffness" and impaired contractility. Complete normalization was not required for successful weaning of MCS.

Keyphrases

heart failure
early onset
mechanical ventilation
oxidative stress
left ventricular
smooth muscle
intensive care unit
acute respiratory distress syndrome