Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.
Ryota SakuraiFrederico Pieruccini-FariaBenjamin F CornishJulia FraserMalcolm A BinnsDerek BeatonAllison Ann DilliottDonna KwanJoel RamirezBrian TanChristopher J M ScottKelly M SunderlandMaria Carmela TartagliaElizabeth C FingerLorne ZinmanMorris FreedmanPaula M McLaughlinRichard H SwartzSean SymonsAnthony E LangRobert BarthaSandra E BlackMario MasellisRobert A HegeleWilliam E McIlroynull nullManuel Montero-OdassoPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
APOE E4 and slow gait are risk factors for cognitive decline in neurodegenerative diseases. Slow gait and smaller gray matter volumes are associated, independently of APOE E4. Worse cognition in APOE E4 carriers with slow gait is explained by smaller GM volume. Gait slowness in APOE E4 carriers indicates poorer cognition-related brain changes.