Multifunctional Theranostic Graphene Oxide Nanoflakes as MR Imaging Agents with Enhanced Photothermal and Radiosensitizing Properties.
Jaber BeikZahra AlamzadehMehri MirrahimiAbolfazl SarikhaniTahereh Shakerian ArdakaniMohamadreza AsadiRasoul IrajiradMehraban MirrahimiVahid Pirhajati MahabadiNeda EslahiJeff W M BulteHabib GhaznaviAli Shakeri-ZadehPublished in: ACS applied bio materials (2021)
The integration of multiple therapeutic and diagnostic functions into a single nanoplatform for image-guided cancer therapy has been an emerging trend in nanomedicine. We show here that multifunctional theranostic nanostructures consisting of superparamagnetic iron oxide (SPIO) and gold nanoparticles (AuNPs) scaffolded within graphene oxide nanoflakes (GO-SPIO-Au NFs) can be used for dual photo/radiotherapy by virtue of the near-infrared (NIR) absorbance of GO for photothermal therapy (PTT) and the Z element radiosensitization of AuNPs for enhanced radiation therapy (RT). At the same time, this nanoplatform can also be detected by magnetic resonance (MR) imaging because of the presence of SPIO NPs. Using a mouse carcinoma model, GO-SPIO-Au NF-mediated combined PTT/RT exhibited a 1.85-fold and 1.44-fold higher therapeutic efficacy compared to either NF-mediated PTT or RT alone, respectively, resulting in a complete eradication of tumors. As a sensitive multifunctional theranostic platform, GO-SPIO-Au NFs appear to be a promising nanomaterial for enhanced cancer imaging and therapy.
Keyphrases
- cancer therapy
- iron oxide
- drug delivery
- photodynamic therapy
- radiation therapy
- gold nanoparticles
- magnetic resonance
- reduced graphene oxide
- fluorescence imaging
- sensitive detection
- contrast enhanced
- signaling pathway
- drug release
- lps induced
- oxidative stress
- early stage
- high resolution
- locally advanced
- magnetic resonance imaging
- papillary thyroid
- pi k akt
- computed tomography
- immune response
- inflammatory response
- mass spectrometry
- mesenchymal stem cells
- lymph node metastasis