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Pd-Catalyzed Cascade Cyclization/Thiocarbonylation with Thioformates: Synthesis of Thioester-Functionalized Oxindoles.

Xi-Wei ZhuHao YeYi-Yun PanYanan WuXin-Xing Wu
Published in: The Journal of organic chemistry (2024)
A Pd-catalyzed thiocarbonylative cyclization of N-( o -iodoaryl)acrylamides with easily accessible thioformates has been developed. The reaction has a wide substrate scope with good yields and represents a powerful route to the synthesis of thioester-functionalized oxindoles. Both S -aryl and alkyl thioformates as the thioester sources were well tolerated. The active Pd-CO intermediate may play an important role in the transformation process.
Keyphrases
  • room temperature
  • quantum dots
  • molecularly imprinted
  • drinking water
  • mass spectrometry