Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.
Keyphrases
- cell adhesion
- insulin resistance
- stem cells
- tyrosine kinase
- signaling pathway
- oxidative stress
- adipose tissue
- cell death
- type diabetes
- endoplasmic reticulum stress
- metabolic syndrome
- high fat diet
- cell cycle arrest
- polycystic ovary syndrome
- reactive oxygen species
- binding protein
- cell migration
- case control
- protein protein