Recalcitrant Optic Nerve and Retinal Infiltration in a Relapse of Acute Lymphoblastic Leukaemia.
Corrina P AzarconGary John V MercadoRachelle N AlfonsoPublished in: Neuro-ophthalmology (Aeolus Press) (2021)
Isolated ocular relapse of leukaemia is rare. We present the case of a 20-year-old male with T-cell acute lymphoblastic leukaemia (ALL) who reported sudden blurring of vision in both eyes 6 months after documentation of ALL remission. Ocular examination showed bilateral infiltrative optic neuropathies and serous retinal detachments. Cerebrospinal fluid and bone marrow samples were negative for blast cells. Systemic work-up did not reveal any other sites of involvement. The ocular infiltration partially responded to reinduction chemotherapy, intraconal steroids, and radiotherapy. This report demonstrates a challenging case of isolated ocular ALL relapse presenting as bilateral optic nerve and retinal infiltration.
Keyphrases
- optic nerve
- optical coherence tomography
- bone marrow
- liver failure
- cerebrospinal fluid
- free survival
- respiratory failure
- diabetic retinopathy
- drug induced
- locally advanced
- induced apoptosis
- high grade
- early stage
- radiation therapy
- mesenchymal stem cells
- aortic dissection
- hepatitis b virus
- genome wide
- squamous cell carcinoma
- case report
- cell cycle arrest
- gene expression
- radiation induced
- endoplasmic reticulum stress
- cell proliferation
- dna methylation
- rectal cancer