Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry (Sarcomeric Human Cardiomyopathy).
Sarah Abou AlaiwiThomas M RostonPeter MarstrandBrian Lee ClaggettVictoria N ParikhAdam S HelmsJodie InglesRachel LampertNeal K LakdawalaMichelle MichelsAnjali Tiku OwensJoseph W RossanoSara SaberiDominic J R AbramsEuan A AshleyChristopher SemsarianJohn C StendahlJames Simon WareErin MillerThomas D RyanMark W RussellSharlene M DayIacopo OlivottoChristoffer Rasmus VissingCarolyn Y HoPublished in: Circulation (2023)
Patients with childhood-diagnosed HCM have a significantly higher lifetime risk of developing LVSD, and LVSD emerges earlier than for patients with adult-diagnosed HCM. Regardless of age at diagnosis with HCM or LVSD, the prognosis with LVSD is poor, warranting careful surveillance for LVSD, especially as children with HCM transition to adult care.
Keyphrases
- hypertrophic cardiomyopathy
- left ventricular
- heart failure
- end stage renal disease
- childhood cancer
- acute myocardial infarction
- cardiac resynchronization therapy
- ejection fraction
- left atrial
- mitral valve
- young adults
- chronic kidney disease
- aortic stenosis
- healthcare
- endothelial cells
- newly diagnosed
- early life
- peritoneal dialysis
- palliative care
- blood pressure
- prognostic factors
- quality improvement
- oxidative stress
- patient reported outcomes
- acute coronary syndrome
- coronary artery disease
- affordable care act
- health insurance
- aortic valve
- atrial fibrillation