A novel human stem cell-based biomarker assay for in vitro assessment of developmental toxicity.

Amer JamalpoorSabine HartveltMyrto DimopoulouTom ZwetslootInger BrandsmaPeter I RaczTorben OsterlundGiel Hendriks

Published in: Birth defects research (2022)

The assay, which we named ReproTracker®, is a state-of-the-art in vitro method that can identify the teratogenicity potential of new pharmaceuticals and chemicals and signify the outcome of in vivo test systems.

Keyphrases

stem cells
high throughput
endothelial cells
induced pluripotent stem cells
oxidative stress
risk assessment
single cell
oxide nanoparticles