Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.
Lin LiYusuke MatsuiMary K PrahlArianna G CassidyYarden GolanUnurzul JigmeddagvaNida OzarslanChristine Y LinSirirak BuarpungVeronica J GonzalezMegan A ChidboyEmilia BasilioKara L LynchDongli SongPriya JegatheesanDaljeet S RaiBalaji GovindaswamiJordan NeedensMonica P RinconLeslie MyattTaha Y TahaMauricio MontanoMelanie OttWarner C GreeneStephanie L GawPublished in: NPJ vaccines (2024)
Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy.
Keyphrases
- sars cov
- immune response
- preterm birth
- pregnancy outcomes
- high glucose
- advanced non small cell lung cancer
- diabetic rats
- pregnant women
- respiratory syndrome coronavirus
- binding protein
- drug induced
- gene expression
- machine learning
- big data
- dengue virus
- inflammatory response
- zika virus
- physical activity
- transcription factor
- data analysis