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Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer.

Katy J McCannAdrian von WitzlebenJaya ThomasChuan WangOliver WoodDivya SinghKonstantinos BoukasKaïdre BendjamaNathalie SilvestreFinn Cilius NielsenGareth ThomasTilman Sanchez-ElsnerJason GreenbaumStephen SchoenbergerBjoern PetersPandurangan VijayanandNatalia SavelyevaChristian Hermann Ottensmeier
Published in: Journal for immunotherapy of cancer (2022)
Our study demonstrates the feasibility of efficiently identifying tumor-specific neoantigens that can be targeted by vaccination in tumors with a low mutational burden, promising successful clinical exploitation, with trials currently underway.
Keyphrases
  • cancer therapy
  • drug delivery