4-Octyl itaconate alleviates experimental autoimmune prostatitis by inhibiting the NLRP3 inflammasome-induced pyroptosis through activating Nrf2/HO-1 pathway.

Xiaohu ZhaoRui FengJuan ChenQing JiangXiaoliang HuaChao-Zhao Liang

Published in: The Prostate (2023)

The present study indicates that 4-OI can alleviates EAP by inhibiting the NLRP3 inflammasome-induced pyroptosis through activating Nrf2/HO-1 pathway, which may facilitate a novel approach toward prostatitis treatment.

Keyphrases

nlrp inflammasome
signaling pathway
diabetic rats
high glucose
oxidative stress
drug induced
pi k akt
multiple sclerosis
mouse model
endothelial cells