Login / Signup

PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells.

Sarah WangCaroline P RiedstraYu ZhangSwetha AnandhAndrew C Dudley
Published in: British journal of cancer (2023)
PTEN loss facilitates perivascular brain colonisation and invasion of melanoma. TGFβ-AKT signalling partially contributes to this phenotype, but further studies are needed to determine the complementary mechanisms that enable melanoma cells to both survive and spread along the brain vasculature.
Keyphrases
  • white matter
  • resting state
  • cell proliferation
  • cell migration
  • cerebral ischemia
  • signaling pathway
  • multiple sclerosis
  • epithelial mesenchymal transition