Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae.

Benneth Ben-AzuEmuesiri Goodies MokeLilian E Chris-OzokoEfe J Jaiyeoba-OjighoOlusegun G AdebayoAbayomi Mayowa AjayiMega O OyovwiGideon OdjugoVincent I OmozojieGoddey EjomafuweNzubechukwu OnikeAya-Ebi O EneniChukwuyenum P Ichipi-IfukorIfeakachuku F Achuba

Published in: Psychopharmacology (2024)

Our data suggest that diosgenin reverses SDS + EtOH interaction-induced behavioral changes via normalization of hypothalamic-pituitary-adrenal axis, neurochemical neurotransmissions, and inhibition of oxidative and inflammatory mediators in mice brains.

Keyphrases

high glucose
diabetic rats
oxidative stress
healthcare
electronic health record
high fat diet induced
big data
alcohol consumption
mouse model
growth hormone
clinical trial
adipose tissue
deep learning