A MEKK1 - JNK mitogen activated kinase (MAPK) cascade module is active in Echinococcus multilocularis stem cells.
Kristin StollMonika BergmannMarkus SpiliotisKlaus BrehmPublished in: PLoS neglected tropical diseases (2021)
We provide evidence for the expression of a MEKK1-JNK MAPK cascade module which, in mammals, is crucially involved in stress responses, cytoskeletal rearrangements, and apoptosis, in E. multilocularis stem cells. Inhibitor studies indicate an important role of JNK signalling in E. multilocularis stem cell survival and/or maintenance. Our data are relevant for molecular and cellular studies into crosstalk signalling mechanisms that govern Echinococcus stem cell function and introduce the JNK signalling cascade as a possible target of chemotherapeutics against echinococcosis.
Keyphrases
- signaling pathway
- stem cells
- cell death
- induced apoptosis
- oxidative stress
- pi k akt
- endoplasmic reticulum stress
- protein kinase
- cell cycle arrest
- cell therapy
- case control
- electronic health record
- tyrosine kinase
- big data
- inflammatory response
- machine learning
- toll like receptor
- mesenchymal stem cells
- bone marrow
- data analysis