Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression.

Jelena BakusicE VriezeM GhoshD A PizzagalliB BekaertS ClaesL Godderis

Published in: Clinical epigenetics (2021)

Our results provide the first evidence of Val66Met susceptibility to differential epigenetic regulation of BDNF exons in reward learning and executive functioning in MDD, which needs to be further explored.

Keyphrases

tyrosine kinase
stress induced
major depressive disorder
dna methylation
prefrontal cortex
genome wide
working memory
bipolar disorder