Rapid tumor-labeling kinetics with a site-specific near-infrared anti-CEA nanobody in a patient-derived orthotopic xenograft mouse model of colon cancer.

Thinzar M LwinMichael A TurnerSiamak AmirfakhriHiroto NishinoPieterjan DebieBard C CosmanRobert M HoffmanSophie Hernot Michael Bouvet

Published in: Journal of surgical oncology (2021)

Fluorescent anti-CEA nanobodies rapidly and specifically labeled colon cancer in cell-line-based and patient-derived orthotopic xenograft (PDOX) models. The kinetics of nanobodies allow for same day administration and imaging. Anti-CEA-nb-800 is a promising and practical molecule for FGS of colon cancer.

Keyphrases

mouse model
high resolution
pet imaging
mass spectrometry
pet ct
single molecule