A triple-targeting delivery system carrying two anticancer agents.

Hui LiChang-Hee LeeInjae Shin

Published in: Organic & biomolecular chemistry (2021)

To improve tumor selectivity, a triple-targeting delivery system (Oct-FK(PBA-Az)-Dox) carrying two anticancer agents (apoptozole (Az) and doxorubicin (Dox)) was designed and synthesized. The results showed that both anticancer agents in Oct-FK(PBA-Az)-Dox are liberated in the presence of both H2O2 and cathepsin B, which are normally present at high levels in tumors.

Keyphrases

cancer therapy
optical coherence tomography
diabetic retinopathy
drug delivery
optic nerve