Mesenteric Adipose Tissue Contributes to Intestinal Fibrosis in Crohn's Disease Through the ATX-LPA Axis.

Liang-Yu HuangWenwei QianYihan XuZhen Guo Yi YinFeilong GuoWeiming ZhuYi Li

Published in: Journal of Crohn's & colitis (2022)

The ATX-LPA axis regulated intestinal fibrosis by influencing the proliferation and differentiation of intestinal fibroblasts. Inhibiting this axis may be a therapeutic target for intestinal fibrosis in CD.

Keyphrases

adipose tissue
signaling pathway
type diabetes
liver fibrosis
metabolic syndrome
extracellular matrix