GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions.
Huazhang ZhuWeizhen ZhangYingying ZhaoXingsheng ShuWencong WangDandan WangYangfan YangZhijun HeXiaomei WangYing YingPublished in: Molecular neurodegeneration (2018)
Our study proposes mild retinal tauopathy as a new pathophysiological model for DR and tau as a novel therapeutic target to counter diabetic RGCs neurodegeneration occurring before retinal vasculature abnormalities.