Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
Zongtao LiuNianguo DongHaipeng HuiYixuan WangFayun LiuLi XuMing LiuZhenqi RaoZhen YuanYuqiang ShangJun FengZhejun CaiFei LiPublished in: European heart journal (2022)
The reduction in endothelial-dependent BH4 levels promoted peroxynitrite formation, which subsequently resulted in DRP1 tyrosine nitration and osteoblastic differentiation of VICs, thereby leading to aortic valve calcification. Supplementation of FA in diet attenuated hypercholesterolaemia-induced aortic valve calcification by salvaging BH4 bioavailability.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- endothelial cells
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- chronic kidney disease
- high glucose
- physical activity
- weight loss
- heart failure
- vascular smooth muscle cells
- left ventricular
- fluorescent probe
- vascular endothelial growth factor