Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles.

Published in: BMC pharmacology & toxicology (2018)

The use of HPMC and Pluronic F127 produced SQV SDNs with improved permeation in Caco-2 cells and improved accumulation in CEM cells, but negative effects with PVA.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
signaling pathway
emergency department
oxidative stress
cell proliferation
pi k akt