Alemtuzumab induced red cell aplasia and other immune cytopenias - not so 'pure'.
Lucy AitkenRonak PatelJames D RozarioPhilip Young-Ill ChoiPublished in: Immunotherapy (2021)
We report on the presentation and outcome of a 28-year-old female who developed red cell aplasia following alemtuzumab therapy for relapsing remitting multiple sclerosis. The patient also developed synchronous immune thrombocytopenia and immune neutropenia, but not aplastic anemia. This patient received high dose steroids, intravenous immunoglobulin (iv.Ig), rituximab, red cell transfusions, vincristine, G-CSF, cyclosporin and mycophenolate to treat the combination of cytopenias over a period of 6 months with subsequent improvement in bone marrow function. While alemtuzumab has several recognized autoimmune complications, little is known about the potential hematological side effects. The combination of red cell aplasia, immune thrombocytic purpura and autoimmune neutropenia has not previously been described in the literature following alemtuzumab immunotherapy and highlights the importance of monthly blood monitoring post alemtuzumab administration.
Keyphrases
- multiple sclerosis
- single cell
- high dose
- bone marrow
- cell therapy
- case report
- low dose
- stem cells
- mesenchymal stem cells
- drug induced
- systematic review
- diffuse large b cell lymphoma
- climate change
- systemic lupus erythematosus
- stem cell transplantation
- disease activity
- cerebrospinal fluid
- risk factors
- hodgkin lymphoma
- high glucose
- chemotherapy induced