Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN.
Poh-Yi GanAndrea S GodfreyJoshua D OoiKim-Maree O'SullivanVirginie OudinArthur Richard KitchingStephen R HoldsworthPublished in: Journal of the American Society of Nephrology : JASN (2019)
These findings in a mouse model indicate that administering apoptotic splenocytes conjugated with the immunodominant MPO peptide suppresses anti-MPO GN by inducing antigen-specific tolerance.