The role of synaptic biomarkers in the spectrum of neurodegenerative diseases.
Sonia MazzucchiGiovanni PalermoNicole CampeseAlessandro GalganiAlessandra Della VecchiaAndrea VergalloGabriele SicilianoRoberto CeravoloHarald HampelFilippo BaldacciPublished in: Expert review of proteomics (2020)
CSF Ng revealed a role as a diagnostic and prognostic biomarker in NDD. Ng increase seems to be very specific for typical AD phenotype, probably for a prevalent hippocampal involvement. Synaptic biomarkers may serve different context-of-use in AD and other NDD including prognosis, diagnosis, and tracking synaptic damage - a critical pathophysiological mechanism in NDD - thus representing reliable tools for a precision medicine-oriented approach to NDD.