Angiogenesis in abnormal uterine bleeding: a narrative review.
Mei-An MiddelkoopEmma E DonWouter J K HehenkampNicole J PolmanArjan W GriffioenJudith A F HuirnePublished in: Human reproduction update (2023)
AUB-E and AUB-I are most likely associated with aberrant endometrial angiogenesis and impaired vessel maturation. This review supports existing evidence that increased proangiogenic and decreased antiangiogenic factors cause impaired vessel maturation, resulting in more fragile and permeable vessels. This matches our hypothesis and these mechanisms appear to play an important role in the pathophysiology of AUB-E and AUB-I. Exploring the alterations in angiogenesis in these patients could provide treatment targets for AUB.