A randomized masked pilot clinical trial to compare the efficacy of topical 1% voriconazole ophthalmic solution as monotherapy with combination therapy of topical 0.02% polyhexamethylene biguanide and 0.02% chlorhexidine in the treatment of Acanthamoeba keratitis.
Bhupesh BaggaSavitri SharmaRuchi Pratap Singh GourAshik MohamedJoveeta JosephVarsha M RathiPrashant GargPublished in: Eye (London, England) (2020)
These outcomes suggest that topical VZ as a monotherapy in AK treatment is effective and comparable to BG combination therapy but needs trials with larger sample size and longer follow-up to provide conclusive evidence.