Cross-linking by tissue transglutaminase-2 alters fibrinogen-directed macrophage proinflammatory activity.

Lauren G PooleAnna K KopecMatthew J FlickJames P Luyendyk

Published in: Journal of thrombosis and haemostasis : JTH (2022)

The results indicate that atypical cross-linking by TG2 imparts unique proinflammatory activity to surface-adhered fibrinogen. The results suggest a novel coagulation-independent mechanism controlling fibrinogen-directed macrophage activation.

Keyphrases

adipose tissue