Glucagon stimulation test to assess growth hormone status in Prader-Willi syndrome.
L CasamitjanaO Giménez-PalopR CorripioR ParejaE BerlangaM RiglaJ C OlivaAssumpta CaixàsPublished in: Journal of endocrinological investigation (2020)
Fixed-dose (1 mg) GST using a peak GH cutoff of < 3 ng/mL or < 1 ng/mL promises to be useful for screening for GHD in adults and late adolescents with PWS. However, in those weighing > 90 kg, the < 1 ng/mL cutoff seems better. Larger studies are necessary to establish definitive glucagon doses and cutoffs, especially in extremely obese patients.