Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects.
Zhen FanMelanie DaniGrazia D FemminellaMelanie WoodValeria CalsolaroMattia VeroneseFederico TurkheimerSteve GentlemanDavid J BrooksRainer HinzPaul EdisonPublished in: European journal of nuclear medicine and molecular imaging (2018)
This study demonstrates for the first time that spectral analysis can be used to generate parametric maps of 11C-PBR28 uptake, and is able to detect microglial activation in amyloid-positive MCI subjects. IRF parametric maps of 11C-PBR28 uptake allow voxel-wise single-subject analysis and could be used to evaluate microglial activation in individual subjects.
Keyphrases
- mild cognitive impairment
- cognitive decline
- optical coherence tomography
- lipopolysaccharide induced
- lps induced
- inflammatory response
- computed tomography
- traumatic brain injury
- immune response
- neuropathic pain
- high resolution
- dendritic cells
- cognitive impairment
- positron emission tomography
- brain injury
- subarachnoid hemorrhage
- contrast enhanced