Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis.

Xia LiYu ZhangQuan JinKai-Li XiaMin JiangBen-Wen CuiYan-Ling WuShun-Zong SongLi-Hua Lian Ji-Xing Nan

Published in: British journal of pharmacology (2018)

Activation of LKB1/AMPK signalling by gentiopicroside was mediated by the P2X7 receptor-NLRP3 inflammasome, suggesting the therapeutic value of blocking P2X7 receptors in the treatment of alcoholic hepatosteatosis.

Keyphrases

protein kinase
nlrp inflammasome
liver injury
drug induced
mouse model
skeletal muscle
combination therapy