Down-regulation of EVA1A by miR-103a-3p promotes hepatocellular carcinoma cells proliferation and migration.

Qian XuZhaozhong LiaoZunshuang GongXiaokun LiuYuling YangZhe WangWeiyan YangLin HouJiejie YangJunying SongWenjing LiuBin WangJunnan HuaMingyi PuNing Li

Published in: Cellular & molecular biology letters (2022)

These findings indicate that the downregulation of the tumor suppressor EVA1A by miR-103a-3p potentially acts as a key mediator in HCC progression, mainly by inhibiting apoptosis and promoting metastasis. The miR-103a/EVA1A/TP53 axis provides a new potential diagnostic and therapeutic target for HCC treatment.

Keyphrases

cell proliferation
signaling pathway
long non coding rna
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
human health
replacement therapy
climate change
smoking cessation