Amiloride Reduces Urokinase/Plasminogen-Driven Intratubular Complement Activation in Glomerular Proteinuria.
Gustaf L IsakssonGitte R HinrichsHenrik AndersenMarie L BachKathrin WeyerRikke ZacharJan Erik HenriksenKirsten MadsenIda K LundGeraldine MolletClaus BistrupHenrik BirnBoye L JensenYaseelan PalarasahPublished in: Journal of the American Society of Nephrology : JASN (2024)
In conditions with proteinuria, uPA-plasmin generates anaphylatoxins in tubular fluid and promotes downstream complement activation sensitive to amiloride. This mechanism links proteinuria to intratubular proinflammatory signaling. In perspective, amiloride could exert reno-protective effects beyond natriuresis and blood pressure reduction.