P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis.

Ruo-Xue WenHui ShenShu-Xian HuangLi-Ping WangZong-Wei LiPeng PengMuyassar MamtilahunYao-Hui TangFan-Xia ShenHeng-Li TianPan-Ting Zhou Zhi-Jun Zhang

Published in: CNS neuroscience & therapeutics (2020)

Our results indicate that P2Y6 receptor-mediated microglial phagocytosis plays a beneficial role during the acute stage of ischemic stroke, which can be a therapeutic target for ischemic stroke.

Keyphrases

brain injury
subarachnoid hemorrhage
cerebral ischemia
inflammatory response
lipopolysaccharide induced
atrial fibrillation
lps induced
neuropathic pain
liver failure
respiratory failure
drug induced
ischemia reperfusion injury
spinal cord
oxidative stress
acute respiratory distress syndrome